Vitamin D and Inflammation презентация

Vitamin D and Inflammation Arranged by: Intern Student Moh.Reshad shahabi

Objectives Describe the physiologic functions of Vitamin D. Relate the effects of Vitamin D deficiency to inflammatory disease states. Identify the influence of Vitamin D deficiency on health. (физиологические функции витамина D. эффекты дефицита витамина D к воспалительным болезненных состояний. Определить влияние дефицита витамина D на здоровье.)

Vitamin D: What is it? Fat soluble vitamin (stored in fat) Hormone precursor acts more like a hormone than a vitamin “neRelated to steroid hormones urosteroid”, endogenous, synthesized from cholesterol, regulator of a number of genes Exists in 2 forms D3, D2

Active vs. Inactive Vitamin D

HypoVitaminosis D Sufficient Vitamin D Serum 25(OH)D >30 ng/ml Vitamin D Insufficiency Serum 25(OH)D 21-29 ng/ml Vitamin D Deficiency Serum 25(OH)D < 20 ng/ml (<50nmol/L) Mild (20-30ng/nl), moderate (5-10 ng/ml), severe (<5ng/ml)

Other Physiologic Functions of Vitamin D Modulates immune system/pro-inflammatory cytokines= reduction of inflammation Deficiency: arthritis, lupus, IBS, Multiple sclerosis Inhibits Cell growth/angiogenesis/differentiation Deficiency: cancer (prostrate, breast, colon) Glucose metabolism/pancreatic B-cell function/ insulin sensitivity Deficiency: diabetes mellitus

Physiologic Functions of Vitamin D Influences smooth muscle tone, endothelium, cardiomyocytes, controls intracellular Ca+, RAAS Deficiency: cardiovascular disease, hypertension, stroke Anti-oxidative/neuroprotective Deficiency: dementia, Alzheimer's, schizophrenia, depression Neuromuscular stability Deficiency: myofascial pain, musculoskeletal pain, myopathy

At Risk for Vitamin D Deficiency Lower circulating Vitamin D Inadequate sun exposure in chronically ill, institutionalized or homebound poor dietary intake Aging (> 50 years) Obesity (body mass index > 30 kg/m2)-body fat sequesters the vitamin Sun protective clothing/sunblock (SPF 30)

Known Fact… People

Source: Forrest, K. Y., & Stuhldreher, W. L. (2011). Prevalence and correlates of vitamin D deficiency in US adults. Nutrition Research, 31(1), 48-54. www.health.harvard.edu